A Retrospective Review of Cases of SJS and TEN in a Tertiary Care Hospital, Bangalore.

Published on:
Indian Journal of Pharmacy Practice, 2008; 1(1):50-54
Research Article | doi:Nill


A Retrospective Review of Cases of SJS and TEN in a Tertiary Care Hospital, Bangalore.


Authors and affiliation (s):

Ramjan Shaik , Sacchidanand S , Shobha Rani R Hiremath , Geeta Pradeep

1,3 . Dept of Pharmacy Practice, Al-Ameen College of Pharmacy, Bangalore-560027,

2.Former Head, Department of Skin and STD , Victoria Hospital, Bangalore and currently Registrar (Evaluation), Rajiv Gandhi University of Health Sciences (RGUHS), Karnataka,

4 Lecturer , Dept of Pharmacy Practice, Charles Sturt University, Orange, Australia

Abstract:

Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN) are rare bullous dermatologic reactions accounting for 0.05 to 2 persons per 1 million population per year. Medicinal agents are an important cause of SJS and TEN. The medical and economic impact of these reactions is therefore greater than might be expected on the basis of incidence. Therefore, we conducted a retrospective review of cases of SJS and TEN from the year 2001 to 2006 as referred by the Department of Dermatology, Victoria Hospital, Bangalore, to quantify the association of specific medicines with the same. Data were collected from the database of the department which was prepared by our faculty using the case sheets and by talking to the patients/relatives as and when cases were reported. A total of 53 cases of SJS and TEN were identified out of which 28(53%) cases were reported to have SJS and 25(47%) cases were TEN. It was found that 35(66%) were male and 18(34%) were female. Out of 53 cases 33(62%) were adults and 8(15%) were geriatric. Antibiotics were the main medicines that caused SJS followed by anticonvulsants and in case of TEN, anticonvulsants were the main agents. Out of 28 SJS cases, 17(61%) cases led to hospitalization and among 25 TEN cases, 5(20%) cases led to hospitalization. One TEN case resulted in the death of the patient, accounting for (4%) of the total number of TEN reactions. Thus, it can be concluded that ADR monitoring program helps in detecting the ADRs like SJS, TEN and many others which can help physicians in correct medical decision making and also can prove in promoting better patient care.

Key Words: Stevens Johnson Syndrome SJS, Toxic Epidermal Necrolysis TEN




 

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