Background Cinchona bark, which contains quinine, is known to have been used in Europe since 1633 for prophylaxis and treatment of malaria. The commonest symptoms of overdose are tinnitus, nausea, vomiting, hearing impairment, 1,2 vasodilation and sweating .While all of the cinchona alkaloids can cause visual disturbances, only quinine is 3 known to cause blindness. The commonest permanent disability is visual field restriction, which is frequently 1, 2, 4 severe and may require the patient to be placed on the blind register . The vast majority of patients show some improvement with transient blindness lasting for 1 h to 50 days. Between 8 and 14 h is the typical of the length of time between developing blindness and the first perception of light. In general, visual recovery is only partial, with the peripheral vision being the most affected. Key words: Quinine, Visual loss.