Isoniazid Associated Psychosis: A Case Series of 3 Patients

Published on:August 2017
Indian Journal of Pharmacy Practice, 2017; 10(2):142-146
Case Series | doi:10.5530/ijopp.10.2.29


Isoniazid Associated Psychosis: A Case Series of 3 Patients


Authors and affiliation (s):

Vineetha Bharathan Menon1*, Rinu Shaji2, Pratibha Pereira3, Shashidhara Kuppegala Chikkaveeraiah4 Madhan Ramesh5

1Doctoral Research Scholar, Department of Pharmacy Practice, JSS College of Pharmacy, JSS University, Mysore- 15, Karnataka, INDIA.

2Pharm.D Intern, Department of Pharmacy Practice, JSS College of Pharmacy, JSS University, Mysore- 15, Karnataka, INDIA.

3Associate Professor, Department of General Medicine, JSS Medical College & Hospital, JSS University, Mysore- 15, Karnataka, INDIA.

4Associate Professor, Department of General Medicine, JSS Medical College & Hospital, JSS University, Mysore- 15, Karnataka, INDIA.

5Professor and Head, Department of Pharmacy Practice, JSS College of Pharmacy, JSS University, Mysore- 15, Karnataka, INDIA.

Abstract:

Background: Isoniazid is the first line agent for the treatment of tuberculosis. Psychosis is a known complication of isoniazid therapy, although infrequent. Case report: One female and two male patients aged 35 years, 55 years and 60 years respectively developed psychosis following isoniazid administration. All the three received 300 mg of isoniazid daily for the management of pulmonary tuberculosis. High dose of isoniazid and low body mass index were identified as the common risk factor for the development of isoniazid associated psychosis. The incidence, possible pathogenesis, risk factors and treatment options are discussed. Conclusion: Isoniazid psychosis is a major complication, which if recognized early can be effectively treated.

Key words: Adverse drug reaction, Anti-tubercular therapy, Case series, Isoniazid, Psychosis.




 

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmacy Practice (IJOPP) [ISSN-0974-8326] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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