Piperacillin- Tazobactam Induced Cutaneous Reaction: A Case Report

Published on:April 2019
Indian Journal of Pharmacy Practice, 2019; 12(2):xx-xx
Case Report | doi:10.5530/ijopp.12.2.x

Piperacillin- Tazobactam Induced Cutaneous Reaction: A Case Report

Authors and affiliation (s):

Syed Zia Inamdar1,*, Pradeepthi Katragadda1, Abhishek Bijjargi2, Raghavendra Vinayakarao Kulkarni1, Pooja Bijjargi2, Bhagyashree Gahtad2

1Department of Pharmacy Practice, BLDEA’s SSM College of Pharmacy and Research Centre, Vijaypur- 586103, Karnataka, INDIA.

2Pharm D Intern, BLDEA’s SSM College of Pharmacy and Research Centre, Vijaypur -586103, Karnataka, INDIA.


Piperacillin tazobactum is an extended spectrum pencillin belonging to uriedopencillin class used in the management of polybacterial infections. A 37 year old male patient admitted to the hospital with the chief complaints of breathlessness since 8 days and cough with expectoration since 2 days. The patient was initially managed with nebulization and bronchodilator therapy with subsequent administration of Piperacillin Tazobactum (4.5 gm) antibiotic to treat underlying infection. The patient complaints the development of pruritis and red color skin rashes over the back of neck after receiving first dose of Piperacillin Tazobactum, the antibiotic was stopped and supportive treatment with antihistamine and corticosteroid was provided to treat allergic reaction. The symptoms were healed and patient condition was improved on discharge. The suspected drug reaction with Piperacillin Tazobactum was found to have “probable” causal relationship through Naranjo causality assessment and pose “moderate” severity as assessed through Hartwig’s Severity scale. The report suggests close monitoring of Piperacillin-Tazobactam usage among patient population.

Key words: Piperacillin- Tazobactum, uriedopencillin, Pruritis, Adverse drug reaction, Naranjo causality assessment,


The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmacy Practice (IJOPP) [ISSN-0974-8326] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 2008.


IJOPP uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2014 are being assigned DOIs for its permanent URLs