The Role of Finasteride in the Management of Androgenetic Alopecia in Male: A Narrative Review

Published on:December 2019
Indian Journal of Pharmacy Practice, 2020; 13(1):3-13
Review Article | doi:10.5530/ijopp.13.1.2


The Role of Finasteride in the Management of Androgenetic Alopecia in Male: A Narrative Review


Authors and affiliation (s):

Anil Tumkur*, Charmine Caryn Teo Cher Ern, Chang Ching Shuang, Amilia Chai Hui Yong, Chan Poh Yee, Chai Tze Leen, Lee Kah Lock, Nermesh Singh

School of Pharmacy, International Medical University, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur, MALAYSIA.

Abstract:

The purpose of this review was to evaluate the role of finasteride, a type-II 5α-reductase inhibitor in the prevention and treatment of androgenetic alopecia (AGA) in males. Finasteride inhibits 5α-reductase and reduce the biosynthesis of dihydrotestosterone (DHT). This inhibition marks a decrease in concentration of DHT and provides a novel and selective approach to androgen deprivation. Clinical trials have proven the safety and efficacy of tablet finasteride 1 mg for AGA. In this review, we discuss all aspects of finasteride, including dosing and indication, pharmacology, pharmacokinetics to its role in the treatment of AGA.

Key words: Androgenic alopecia, DHT, Finasteride, Norwood-Hamilton scale, Safety.




 

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
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