Isoniazid Induced Generalized Lichenoid Drug Eruption: An Unusual Offender

Published on:September 2020
Indian Journal of Pharmacy Practice, 2020; 13(3):271-273
Case Report | doi:10.5530/ijopp.13.3.44


Isoniazid Induced Generalized Lichenoid Drug Eruption: An Unusual Offender


Authors and affiliation (s):

Pratima Singh1,*, Deepak Nathiya1, Sonal Jain2, Preeti Raj1, Supriya Suman1, Balvir Singh Tomar3

1Department of Pharmacy Practice, Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, INDIA.

2Department of Dermatology, Venereology and Leprosy, NIMS University, Jaipur, Rajasthan, INDIA.

3Department of Gastroenterology and Hepatology, NIMS University, Jaipur, Rajasthan, INDIA.

Abstract:

Introduction: Isoniazid also known as isonicotinic acid hydrazide is first line drug in anti-tubercular regimen. We report the case of lichenoid drug eruption due to this drug. Case-Report: A Sixty four-year old man received treatment for transverse myelitis with pulmonary TB. After almost four months of initiation of regimen he developed viloaceous lesions first from back and gradually involving B/L extremities. A skin punch biopsy is indicative of drug-induced lichenoid drug eruption. Isoniazid dechallenge and rechallenge confirmed the diagnosis of “Isoniazid induced lichenoid Drug eruption”. Discussion: Incidence of isoniazid induced CADR is 0.98%. Diagnosis decisionmaking should be on the basis of critical analysis of case. Role of Pharmacovigilance is crucial to understand quality and frequency of adverse drug reactions

Key words: Lichenoid drug eruption, Isoniazid, Tuberculosis, Cutaneous adverse drug eruption, ATT.




 

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
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