Cutaneous Adverse Drug Reactions (CADRs) at a Quaternary Care Hospital in South India: Focus on Reaction Time and Treatment Cost

Published on:September 2020
Indian Journal of Pharmacy Practice, 2020; 13(3):222-227
Research Article | doi:10.5530/ijopp.13.3.36


Cutaneous Adverse Drug Reactions (CADRs) at a Quaternary Care Hospital in South India: Focus on Reaction Time and Treatment Cost


Authors and affiliation (s):

Priya Karunakaran1,*, Anuradha Kakkanatt2, Jyothi Bai2

1Clinical Pharmacist, Department of Clinical Pharmacy, Aster Medcity, Kuttisahib Road, Cheranelloor, Kochi, Kerala, INDIA.

2Department of Dermatology and Venereology, Aster Medcity, Kuttisahib Road, Cheranelloor, Kochi, Kerala, INDIA.

Abstract:

Background: Cutaneous Adverse Drug Reactions (CADRs) are a major problem in drug therapy and is one of the leading causes of morbidity and mortality in health care. The purpose of the study was to evaluate the Mean Reaction Time, Causality, Severity and Preventability of CADRs and Treatment cost associated with CADRs. Methods: A prospective, observational study of patients diagnosed with CADR was carried out over a period of one year in the Department of Dermatology and Department of Clinical Pharmacy at a quaternary care hospital in South India. Diagnosis of CADRs was confirmed by the dermatologist and Clinical Pharmacist evaluated the suspected CADRs for Causality by WHO-UMC and Naranjo’s scale, Severity by Hartwig and Siegel scale and Preventability by Schumock and Thornton criteria. Results: 42 CADRs were reported during the study period. Most commonly manifested CADR was Acneiform Eruption (23.8 %) followed by Maculopapular Rash (19.0%) and drugs used for the management of CADRs accounted for INR 5807.93. Most common offending drug group was Anti-infectives (33.3%) followed by Oral Steroids (23.8%). WHO and Naranjo scale rated 95.2% of CADR as probable and 4.7% as certain/ possible (Naranjo scale). Hartwig and Siegel scale marked 64.20% as moderate, 30.90% as mild and 4.70% as severe CADRs. According to Schumock and Thornton criteria 95.2% of CADR were not preventable and 4.7 % were definitely preventable. Conclusion: Awareness about CADRs is essential for early detection and prevention. The healthcare system should promote mandatory reporting of CADRs for ensuring safe drug use and patient care.

Key words: Cutaneous Adverse Drug Reactions, Reaction Time, Causality, Severity, Preventability.




 

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmacy Practice (IJOPP) [ISSN-0974-8326] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 2008.

DOI HISTORY

IJOPP uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2014 are being assigned DOIs for its permanent URLs