Background: Hibiscus sabdariffa lowers blood pressure, blood glucose and total cholesterol in patients yet healthy individuals widely consume the tea. This study evaluated the effect of Hibiscus sabdariffa tea (HS-tea) on clinical, biochemical and haematological parameters in healthy human volunteers. Materials and Methods: Thirty-two healthy human volunteers were randomized in a two-arm open-labelled parallel study into HS-tea (n=17) and Water group (n=15). Three hundred millilitre of either HS-tea or Water was taken daily for 28 days by the participant and clinical (Systolic blood pressure SBP, fasting blood glucose FBG, total cholesterol TC, etc.), biochemical (alanine aminotransferase ALT, albumin ALB, aspartate aminotransferase AST, Serum creatinine SCr, etc.) and haematological (haematocrit HCT, white blood cells count WBC, total protein TPro, etc.) parameters were measured at baseline and on the 14th and 28th day. Results: Daily intake of HS-tea reduced SBP (9.1%, p=0.008), FBG (8.0%, p=0.006) and TPro (5.8%) but increased WBC (34.3%) on the 28th day compared with baseline values. No change was observed with Water. HS-tea lowered SBP, FBG, TC and ALB significantly on the 28th day compared with Water. No significant difference between HS-tea and Water with liver and kidney function markers (AST, ALT, SCr) and haematological parameters (HCT, WBC, TPro). Conclusion: Daily intake of Hibiscus sabdariffa tea for 28 days is safe and reduced SBP, FBG, TC and ALB in healthy human volunteers. It may be considered as a potential nutraceutical candidate for people at risk of developing hypertension, diabetes and hypercholesterolemia.
Key words: Hibiscus sabdariffa, Hypertension, Diabetes, Hypercholesterolemia, Human, Clinical trial.