Authors and affiliation (s):
Snoviya Suresh Babu P*, Satish S, Ramakrishna Shabaraya A
Department of Pharmacy Practice, Srinivas College of Pharmacy, Valachil, Post Farangipete, Mangalore, Karnataka, INDIA.
ABSTRACT
Cervical cancer remains a significant global health concern. This comprehensive review provides an overview of current and emerging treatments for cervical cancer, aiming to inform clinicians and researchers about recent advancements and future prospects in the field. Current treatment modalities for cervical cancer include surgery, radiotherapy, and chemotherapy, often used in combination depending on the stage and extent of the disease. However, these treatments are associated with considerable morbidity and may not be effective in advanced or recurrent cases. Therefore, there is an urgent need for novel therapeutic approaches. Emerging treatments for cervical cancer encompass a variety of strategies, including targeted therapies, immunotherapy, and gene therapies. Targeted therapies, such as inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor (VEGF), have shown promising results in clinical trials, particularly in combination with standard treatments. Immunotherapy, particularly immune checkpoint inhibitors has revolutionized cancer treatment and holds significant potential for cervical cancer. Additionally, gene therapies, including oncolytic viruses and gene editing technologies, offer innovative approaches to targeting cancer cells while sparing healthy tissue. Looking forward, the integration of these emerging treatments into standard clinical practice has the potential to improve outcomes for patients with cervical cancer. However, further research is needed to optimize treatment regimens, identify biomarkers for patient selection, and overcome resistance mechanisms. Collaborative efforts between clinicians, researchers, and pharmaceutical companies are essential to translate these promising therapies from bench to bedside and ultimately reduce the global burden of cervical cancer.
Keywords: HPV, Chemotherapy, Immunotherapy, Targeted therapy.