Published on: September 2025
Authors and affiliation (s):
Shirly Sasikumar, Mathesh Anandan, Darius Alan, Dhivya Kothandan*
Department of Pharmacy Practice, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai, Tamil Nadu, INDIA.
ABSTRACT
Classical Hodgkin Lymphoma (CHL) is a malignant lymphoproliferative disorder characterized by the presence of Reed-Sternberg cells(R-SC), which are large, multinucleated cells within an inflammatory microenvironment of immune cells, fibrosis, and necrosis. While its exact cause remains unclear, CHL is strongly associated with Epstein-Barr Virus (EBV) infection, genetic factors, and immune dysregulation. Common symptoms include fever, night sweats, unexplained weight loss, pruritus, fatigue, and hepatosplenomegaly. This report presents a rare case of CHL of mixed cellularity in a 35-year-old pregnant woman, who was admitted with generalized pruritus, joint pain, and bilateral upper lymphadenopathy. The diagnosis was confirmed through a PET-CT scan, bone marrow biopsy, and lymph node excision biopsy. The patient was initiated on cycle 1B chemotherapy with adriamycin, vinblastine, dacarbazine, and Brentuximab Vedotin (BV-AVD), along with supportive care and lifestyle modifications to ensure optimal maternal and fetal outcomes.
Keywords: Hodgkin lymphoma, PET-CT, BV-AVD regimen, Supportive Care.