Persistent Invasive Mole: A Case Report

Published on:January 2021
Indian Journal of Pharmacy Practice, 2021; 14(1):68-71
Case Report | doi:10.5530/ijopp.14.1.14

Persistent Invasive Mole: A Case Report

Authors and affiliation (s):

Prathyusha Kusuma1, Bhargavi Neela1, Balasankar Ramavath2,*

1Department of Clinical Pharmacy and Pharm.D, Vaagdevi College of Pharmacy, Hanamkonda, Warangal, Telangana, INDIA.

2Department of Oncology, Kakatiya Medical College, Mahatma Gandhi Memorial Hospital, Warangal, Telangana, INDIA.


Gestational trophoblastic disease is a group of interrelated lesions arising from the trophoblastic epithelium of placenta after abnormal fertilization. It is a disease of women with pregnancy related tumors. Invasive mole, a common manifestation of gestational trophoblastic disease is characterized by villi accompanying trophoblastic overgrowths and invasion which penetrate deep into the myometrium sometimes involving peritoneum or vaginal vault. Here we present a case of persistent invasive mole in a patient who underwent dilation and curettage twice with persistent vaginal bleeding and elevated serum β-human Chorionic Gonadotropin levels. Investigations revealed enlarged uterus with adnexal pathology, Histopathological examination of Dilation and Curettage showed presence of villi and trophoblastic tissue, increased serum β-hCG levels. The patient is successfully treated and managed with methotrexate chemotherapy. This study is focused on the significance of follow-up of the patient as there are more chances of recurrence associated with gestational trophoblastic disease.

Key words: Gestational trophoblastic disease, Invasive mole, β-hCG levels, Chemotherapy, Methotrexate.


The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmacy Practice (IJOPP) [ISSN-0974-8326] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 2008.


IJOPP uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2014 are being assigned DOIs for its permanent URLs