Monoamine oxidase (MAO) activity levels have been described to be associated with the human behavioral aspects such as depressions and other neurological problems. In present study the MAO activity in the plasma of alcohol and tobacco addicted individuals were studied to check it's effect on their MAO activity. The results obtained from above study shows that, the plasma MAO activity is less in alcohol (164.78 ± 1.93 U/ml) and tobacco addicted (193.86 ± 2.97 U/ml) individuals as compared to normal individuals (453.08 ± 2.83 U/ml). This may be happens due to the effect of alcohol and tobacco on the cofactors of enzymatic reactions.
Key words: addiction, depression, monoamine oxidase,