Painful episodes also known as sickle cell crisis are the key symptoms of patients suffering from Sickle cell disease. The presence of other life-threatening conditions such as Beta-thalassemia and Sexually transmitted disease can increase the risk of developing complications and premature deaths in patients. Our case study encountered a 17-yearold male having Sickle cell crisis with Beta-thalassemia and Sexually transmitted disease. Our finding has demonstrated that the etiologic interactions among these conditions were very much dependent upon genetics and transmission via contaminated blood. Managing such a complicated conditions can often bring challenges while planning for therapeutic management. Hence, the foremost goal for managing the patients is to control the signs and symptoms promptly and safely, ultimately improving the quality of life of the patients and decreasing further number of hospitalizations.
Key words: Sickle cell disease, Vaso-occlusive crisis, Beta-thalassemia, Sexually transmitted disease, Case report.