Cefpodoxime Proxetil is an extended spectrum cephalosporin of third generation. It inhibits bacterial cell wall synthesis by binding to one or more of the penicillin binding proteins. We came across two cases for getting oral ulcers after administering Cefpodoxime Proxetil 200 mg which was prescribed for viral fever. We suspected adverse drug reaction as per the temporal relationship. After reviewing previous literatures and database (e.g. Micromedex, UpToDate.) we found that oral ulcers are not proved as an adverse reaction due to Cefpodoxime Proxetil. These rare cases mainly occur due to lack of rapid diagnostic tools, which can concomitantly cause antibiotic resistance in patients and can be a public threat in near future. After prescribing such drugs monitoring of patient is required to prevent any harmful effects. Clinical Pharmacist can play vital role in this field of healthcare.
Keywords: Antibiotic Resistance, Cephalosporin, Cefpodoxime Proxetil, Oral ulcer, Adverse Drug Reaction.