Published on:October 2022

Indian Journal of Pharmacy Practice, 2022; 15(4):334-337

Case Report | doi:10.5530/ijopp.15.4.61


Umme Habeeba A Pathan*, Safiya Anhar

Department of Pharmacy Practice, Bapuji Pharmacy College, Davangere, Karnataka, INDIA.


This case report presents de-challenge of acenocoumarol after abnormal increase of International Normalized Ratio and re-challenge of drug after stabilizing the abnormal values. A 66-year-old female came with the complaints of abdominal distension and bilateral lower limb swelling to a tertiary care hospital’s General Medicine OPD. She had a history of double valve replacement twelve years ago and open-heart surgery for ischemic heart disease four months back. She was on acenocoumarol since four months which is certain cause of drug induced coagulopathy according to World Health Organization causality assessment scale. Acenocoumarol was withheld and low dose of Vitamin K was administered. After the international normalized ratio was below 2, acenocoumarol was re-administered with dose of 0.5 mg, followed by 1 mg for two days and 2 mg for the next day. Obeticholic acid is initiated to prevent further fibrosis of liver. Acenocoumarol induced coagulopathy is a common complication seen with the use as it has varied pharmacokinetics and pharmacodynamics and hence patient should be counseled well about monitoring parameters of anticoagulants. It is required that specific dosing algorithms to be developed for Indians considering the demographics, clinical variables and genetic profile which paves path to the individualized treatment.

Keywords: Acenocoumarol, Adverse Drug Reaction, Causality assessment, Coagulopathy, Dosing algorithm.